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组织工程技术修复关节软骨缺损的研究进展<sup(3)
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摘要:7 展望 组织工程技术在修复关节软骨缺损方面具有巨大潜能,因此近年来受到广泛关注。虽然其在修复关节软骨缺损方面进步巨大,但在实践应用过程中仍
7 展望
组织工程技术在修复关节软骨缺损方面具有巨大潜能,因此近年来受到广泛关注。虽然其在修复关节软骨缺损方面进步巨大,但在实践应用过程中仍有一些问题需要解决。目前仍然需要开发一种新的生物材料,其应具有良好的生物活性并且能够增强材料与细胞之间的相互作用。此外仍需特别关注移植细胞的存活以及与宿主组织的整合问题。幸运的是:充质干细胞、刺激因子和细胞支架的联合精确使用可能为解决这些挑战提供了新的途径。最后,最严峻的挑战是如何将成功的动物实验研究成果服务于临床。如今,有各种各样的软骨组织工程产品,但只有少数能够用于临床试验,其可能原因包括产品的质量控制、稳定性、成本、安全性和专利问题。
[1]Sun X,Yin H,Wang Y,et al.In Situ Articular Cartilage Regeneration through Endogenous Reparative Cell Homing using a Functional Bone Marrow-specific Scaffolding System[J].ACS Appl Mater Interfaces,2018,10(45):-.
[2]冯乃波,常非,韩宇.生物高分子材料在软骨组织工程中的应用[J].中国组织工程研究,2018,22(26):4215-4221.
[3]Mollenhauer J on articular cartilage biology and osteoarthritis[J].Injury-International Journal of the Care of the Injured,2008,39:S5-S12.
[4]Hurley M,Dickson K,Hallett R,et interventions and patient beliefs for people with hip,knee or hip and knee osteoarthritis: a mixed methods review[J].Cochrane Database Syst Rev,2018,4:CD0.
[5]Kanavaki A M,Rushton A,Efstathiou N,et and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence[J].BMJ Open,2017,7(12):e0.
[6]Rauch A,Rembeck E,Kohn treatment of cartilage lesions[J].Orthopade,2018,47(11):965-978.
[7]Avila-Ortiz G,Bartold P M,Giannobile W,et and Cell Therapy Tissue Engineering Approaches for the Management of the Edentulous Maxilla: A Systematic Review[J].Int J Oral Maxillofac Implants,2016,31 Suppl:s121-164.
[8]Di Luca A,Longoni A,Criscenti G,et energy and stiffness discrete gradients in additive manufactured scaffolds for osteochondral regeneration[J].Biofabrication,2016,8(1):0.
[9]Duarte Campos D F,Drescher W,Rath B,et Biomaterials for Articular Cartilage Repair[J].Cartilage,2012,3(3):205-221.
[10]Kashi M,Baghbani F,Moztarzadeh F,et al.Green synthesis of degradable conductive thermosensitive oligopyrrole/chitosan hydrogel intended for cartilage tissue engineering[J].Int J Biol Macromol,2018,107(Pt B):1567-1575.
[11]Hao T,Wen N,Cao J K,et al.The support of matrix accumulation and the promotion of sheep articular cartilage defects repair in vivo by chitosan hydrogels[J].Osteoarthritis and Cartilage,2010,18(2):257-265.
[12]Yu X,Qian G,Chen S,et al.A tracheal scaffold of gelatinchondroitin sulfate-hyaluronan-polyvinyl alcohol with orientated porous structure[J].Carbohydr Polym,2017,159:20-28.
[13]Li A,Wei Y,Hung C,et properties of collagen type XI,a component of cartilage extracellular matrix[J].Biomaterials,2018,173:47-57.
[14]Gullotta F,Izzo D,Scalera F,et evaluation of hMSCs-based engineered cartilage for chondral tissue regeneration[J].Journal of the Mechanical Behavior of Biomedical Materials,2018,86:294-304.
[15]Chen W C,Yao C L,Wei Y H,et osteochondral defect repair potential of autologous rabbit bone marrow cells on type Ⅱ collagen scaffold[J].Cytotechnology,2011,63(1):13-23.
[16]Kui Huang,Qing Li,Yong Li,et Tissue Regeneration: The Roles of Cells,Stimulating Factors and Scaffol[J].Curr Stem Cell Res Ther,2018,13(7):547-567.
[17]Wong C C,Chen C H,Chiu L H,et In Vivo Articular Cartilage Repair by Tissue-Engineered Cartilage Grafts Produced From Auricular Chondrocytes[J].Am J Sports Med,2018,46(3):713-727.
[18]Morille M,Toupet K,Montero-Menei C N,et microcarriers induce mesenchymal stem cell chondrogenesis and stimulate cartilage repair in osteoarthritis[J].Biomaterials,2016,88:60-69.
[19]Yao Hang,Kang Junpei,Li Weichang,et al.Novel β-TCP/PVA bilayered hydrogels with considerable physical and biofunctional properties for osteochondral repair[J].Biomedical Materials,2018,13(1):0.
[20]Jiang J,Tang A,Ateshian G A,et stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair[J].Ann Biomed Eng,2010,38:2183-2196.
[21]Ledesma-Martinez E,Mendoza-Nunez V M,Santiago-Osorio Stem Cells for Periodontal Tissue Regeneration in Elderly Patients[J].J Gerontol A Biol Sci Med Sci,2019,74(9):1351-1358.
[22]Bray L J,Heazlewood C F,Munster D J,et properties of mesenchymal stromal cell cultures derived from the limbus of human and rabbit corneas[J].Cytotherapy,2014,16(1):64-73.
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